Stomach microbe finds a safe haven

Colonic Crypts: Safe Haven from Microbial Products

The notion that the colon's deep crypt pockets provide a protected location that shields stem cells from potentially toxic substances is widely accepted. In this issue of Cell, Kaiko et al. reveal how a metabolite abundantly produced by the gut microbiota can inhibit stem cell proliferation but is blocked from doing so by crypt architecture.

A Genomic Safe Haven for Mutant Complementation in Cryptococcus neoformans

Just as Koch's postulates formed the foundation of early infectious disease study, Stanley Falkow's molecular Koch's postulates define best practice in determining whether a specific gene contributes to virulence of a pathogen. Fundamentally, these molecular postulates state that if a gene is involved in virulence, its removal will compromise virulence. Likewise, its reintroduction should resto...

Lonely No More: p53 Finds Its Kin in a Tumor Suppressor Haven

Moshe Oren p73 transcript (Kaghad et al., 1997) and contains only 499 residues. With the exception of the last five residues, Department of Molecular Cell Biology The Weizmann Institute of Science which are unique to p73␤, the rest of the protein is identical to the corresponding region in p73␣. Even Rehovot 76100 Israel though the two forms appear to differ in some properties (see below), ther...

Study on Gold as a Hedge or Safe Haven for the Stock Market by a Markov Switching Approach

Although gold is no longer a central cornerstone of the international monetary and financial system, it still attracts considerable attention from researchers and investors. Nowadays, many investors manage their risk with valuable assets such as gold. This paper examines the dynamic relationships between gold and stock markets in the Tehran Stock Exchange. We have applied the Markov switching m...

Library as Safe Haven: Disaster Planning, Response, and Recovery